GPR12

GPR12 is an orphan receptor which has been associated with cancer metastasis, Alzheimers and Parkinson's disease. CBD acts as inverse agonist of GPR12, suggesting therapeutic potential to treat any of the mentioned diseases.

GPR6

GPR6 is an orphan receptor which has been associated with Parkinson's disease. CBD acts as inverse agonist of GPR6, suggesting therapeutic potential to treat Parkinson's disease.

GPR3

GPR3 is an orphan receptor which has been associated with Alzheimer's disease. CBD acts as inverse agonist of GPR3, suggesting therapeutic potential to treat Alzheimer's disease.

CB1

CB1 is the main cannabinoid receptor in the brain but is also found in other tissues. CB1 is a G protein-coupled receptor which inhibits adenylyl cyclase and consequently reduces cAMP upon activation. This in turn regulates many second messenger pathways. 

5-HT3A

A2A (Adenosine)

The Adenosine A2A receptor is involved in the neuroprotective action of CBD in Hypoxic-Ischemic injuries

Nav1.1

Nav1.1 is a sodium channel that is primarily expressed in the brain and cardiac muscle where it functions in action potential generation and propagation. Nav1.1 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

TRPV4

TRPV4 is one of the non-GPCR-coupled cannabinoid receptors. TRPs are primarily involved in pain sensation.

TRPV3

TRPV3 is one of the non-GPCR-coupled cannabinoid receptors. TRPs are typically involved in pain sensation.

TRPV2

TRPV2 is one of the non-GPCR-coupled cannabinoid receptors. TRPs are typically involved in pain sensation.