PPARα

PPARα is part of the nuclear receptor family and is therefore one of the non-GPCR cannabinoid receptors. PPAR-alpha is a transcription factor and a major regulator of lipid metabolism in the liver. Low energy typically stimulates PPARα, but PPARα has also been implicated in neuroprotection.

NMDAr

NMDA receptors are sensitive to the neurotransmitter glutamate. NMDArs are best known for their function in neurons as coincidence detectors and consequently their role in learning and memory. NMDArs are not classic cannabinoid receptors but their activity is modulated by cannabinoids.

Nav1.5

Nav1.5 is a sodium channel that is primarily found in cardiac muscle where it is responsible for action potential generation/cardiac muscle contraction. Nav1.5 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

Nav1.2

Nav1.2 is a sodium channel that is involved in action potential generation in neurons and in muscle. Nav1.2 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

Kv4.3

Kv4.3 is a potassium channel that is involved in the repolarisation of action potentials in cardiac muscle. Kv4.3 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

Kv3.1

Kv3.1 is a potassium channel that functions in action potential repolarisation in fast-firing neurons. Kv3.1 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

Kv1.5

Kv1.5 is a potassium channel that is involved in restoring the resting membrane potential after depolarisation. Kv1.5 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

Kv1.2

Kv1.2 is a potassium channel that is responsible for maintaining resting membrane potential and regulating excitability in neurons. Kv1.2 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

K-ATP

K-ATP is a potassium channel that is sensitive to ATP and therefore to cellular energy levels. K-ATP functions to control cellular energy levels.

GPR55

GPR55 is a G protein-coupled receptor which binds with G protein G13. GPR55 stimulates RhoA, Cdc42 and Rac1 upon activation, suggesting a role in cell division and growth.