Nav1.2

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Introduction

Nav1.2 is a sodium channel that is involved in action potential generation in neurons and in muscle. Nav1.2 is not a classic Cannabinoid receptor but its activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on Nav1.2 it is effectively a Cannabinoid receptor.

Chemical Name

sodium channel, voltage-gated, type II, alpha subunit, SCN2A

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Literature Discussion

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References:

Hill, A.J., Jones, N.A., Smith, I., Hill, C.L., Williams, C.M., Stephens, G.J., and Whalley, B.J. (2014). Voltage-gated sodium (NaV) channel blockade by plant cannabinoids does not confer anticonvulsant effects per se. Neurosci. Lett. 566, 269–274.

Distribution Summary

Nav1.2 is found in brain and muscle. The highest density is found in unmyelinated axons and in developing pre-myelinated axons, and also present in neuronal cell bodies and dendrites.

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