Hemopressin

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Introduction

Hemopressin is a recently discovered Endocannabinoid that acts as a CB1 inverse agonist (roughly meaning that it has the opposite action of THC at CB1 receptors). Most cannabinoid receptor ligands are lipids. However, Hemopressin is the founding member of a new class of endocannabindoids: the peptide cannabinoids or PepCanns. As Hemopressin actually has a higher affinity for CB1 than any other true cannabinoid, this justifies Hemopressin being classified as an Endocannabinoid. Hemopressin strongly suppresses pain sensation and eating and may counteract de-myelination in diseases like multiple sclerosis and therefore has considerable therapeutic potential.

Chemical Name

Hemopressin (peptide sequence: PVNFKFLSH)

Wikipedia Entry

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Synthetic Pathways

Hemopressin is a breakdown product of hemoglobin, the protein that delivers oxygen throughout the body.