Lung cancer

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Introduction

Lung Cancer, also known as lung carcinoma, is a malignant lung tumor characterized by uncontrolled cell growth in tissues of the lung. Although there are several subtypes of Lung Cancer, in general cannabinoids such as THC and CBD appear to be therapeutic.

For more information, please, read the general cancer entry from the list of diseases in this website.

Alternative Names

Lung carcinoma

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Prescription Advice

Preclinical data suggests THC and CBD may be therapeutic in Lung Cancer.

Given the nature of the disease, oral application or sublingual application may be beneficial.

For more information, please, read the general cancer entry from the list of diseases in this website.

Please follow generic prescription advice.

Please note that, while based on preclinical and/or clinical research, this prescription advice is solely intended as a guideline to help physicians determine the right prescription. We intend to continuously update our prescription advice based on patient and/or expert feedback. If you have information that this prescription advice is inaccurate, incomplete or outdated please contact us here.

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Literature Discussion

In three different cancer cell lines (A549, H358 and H460) CBD dose dependently (1nM-3μM) increased ICAM-1 and TIMP-1 through TRPV1. In mice carrying human lung cancer xenografts, CBD increased ICAM-1 and TIMP-1 2.6-3.0-fold, inhibiting lung cancer cell invasion and metastasis (Ramer et al., 2012).

In cancer cell lines (A549 and H460) and human metastatic lung cancer cells CBD as well as THC promote ICAM-mediated Lymphokine-Activated Killer cell adhesion and cancer cell lysis (Haustein et al., 2014).

In cancer cell lines (A549 and H460) and human metastatic lung cancer cells CBD induced apoptosis via COX-2 and PPARγ. In A549-xenografted mice CBD caused tumor regression (Ramer et al., 2013).

Literature:

Haustein, M., Ramer, R., Linnebacher, M., Manda, K., & Hinz, B. (2014). cannabinoids increase Lung Cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1. Biochemical Pharmacology, 92(2), 312-325. https://doi.org/10.1016/j.bcp.2014.07.014

Ramer, R., Bublitz, K., Freimuth, N., Merkord, J., Rohde, H., Haustein, M., … Hinz, B. (2012). Cannabidiol inhibits Lung Cancer cell invasion and metastasis via intercellular adhesion molecule-1. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 26(4), 1535-1548. https://doi.org/10.1096/fj.11-198184

Ramer, R., Heinemann, K., Merkord, J., Rohde, H., Salamon, A., Linnebacher, M., & Hinz, B. (2013). COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human Lung Cancer cells. Molecular cancer Therapeutics, 12(1), 69-82. https://doi.org/10.1158/1535-7163.MCT-12-0335