Bladder cancer

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Introduction

Bladder cancers develop from the epithelial lining of the urinary bladder. cannabinoid receptors in the human bladder cancer cells could be targeted to treat the disease, but more research is needed in this field.

For more information, please, read the general cancer entry from the list of diseases in this website.

Alternative Names

Urothelial cell carcinoma

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Prescription Advice

To data, no specific information is available about the treatment of bladder cancer with cannabinoids.

Given the nature of the disease, sublingual application of THC and/or CBD may be beneficial.

For more information, please, read the general cancer entry from the list of diseases in this website.

Please follow generic prescription advice.

Please note that, while based on preclinical and/or clinical research, this prescription advice is solely intended as a guideline to help physicians determine the right prescription. We intend to continuously update our prescription advice based on patient and/or expert feedback. If you have information that this prescription advice is inaccurate, incomplete or outdated please contact us here.

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Literature Discussion

Several research groups are studying the potential treatment of cannabinoids in bladder cancer.

Until now, we know that human bladder cells express the cannabinoid receptors CB1, CB2 and GPR55 (Bakali et al., 2014).

CB2 receptors are upregulated in human bladder cancer (BC) cells RT4 and RT112. Activation of CB2 with synthetic cannabinoid agonist JWH015 induced cytotoxicity in BC and changes in cellular sphingolipids metabolism (Bettiga et al., 2017).

2AG regulates inflammation and proliferation processes of bladder carcinoma cells, probably through CB receptors (Gasperi et al., 2014).  

Literature:

Bakali, E., Elliott, R.A., Taylor, A.H., Lambert, D.G., Willets, J.M., and Tincello, D.G. (2014).Human urothelial cell lines as potential models for studying cannabinoid and excitatory receptor interactions in the urinary bladder. Naunyn. Schmiedebergs Arch. Pharmacol. 387, 581–589.

Bettiga, A., Aureli, M., Colciago, G., Murdica, V., Moschini, M., Lucianò, R., … Benigni, F. (2017). Bladder cancer cell growth and motility implicate cannabinoid 2 receptor-mediated modifications of sphingolipids metabolism. Scientific Reports, 7, 42157. https://doi.org/10.1038/srep42157

Gasperi, V., Evangelista, D., Oddi, S., Florenzano, F., Chiurchiù, V., Avigliano, L., Catani, M.V., and Maccarrone, M. (2014). Regulation of inflammation and proliferation of human bladder carcinoma cells by type-1 and type-2 cannabinoid receptors. Life Sci.