GPR119 is mainly expressed in the pancreas and tissues of the gastrointestinal tract. GPR119 binds to endocannabinoids Anandamide, 2OG, PEA and OEA (Overton et al., 2006).
GPR119 is involved in food intake and glucose homeostasis (keeping blood glucose levels within acceptable limits). OEA is actually the strongest endogenous activator of GPR119 and was shown to reduce food intake and weight gain in rodents via PPARα and TRPV1 (Overton et al., 2006).
endocannabinoids such as OEA bind to GPR119 to increase cAMP (signals high energy/glucose content to a cell), stimulate insulin secretion and cause fat deposition (Overton et al., 2006).
Overton, H.A., Babbs, A.J., Doel, S.M., Fyfe, M.C.T., Gardner, L.S., Griffin, G., Jackson, H.C., Procter, M.J., Rasamison, C.M., Tang-Christensen, M., et al. (2006). Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 3, 167–175.