GlyR

Left Top

Introduction

Glycine receptors are sensitive to Glycine and produce a hyperpolarising current upon activation. GlyRs are not classic cannabinoid receptora but their activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on GlyRs they are effectively cannabinoid receptors.

Chemical Name

Glycine receptor

IUPHAR entry

Wikipedia Entry

Tags

Bottom

Literature Discussion

Anandamide Δ9THC  

References:

Pertwee, R.G., Howlett, A.C., Abood, M.E., Alexander, S.P.H., Di Marzo, V., Elphick, M.R., Greasley, P.J., Hansen, H.S., Kunos, G., Mackie, K., et al. (2010). International Union of Basic and Clinical Pharmacology. LXXIX. cannabinoid receptors and their ligands: beyond CB₁ and CB₂. Pharmacol. Rev. 62, 588–631.  

Distribution Summary

GlyRs ar widely distributed throughout the central nervous system with particularly high expression in the spinal cord and brain stem.

Distribution from Human Protein Atlas: 
PDF Download: